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KMID : 1143120140040030180
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Asia Pacific Allergy
2014 Volume.4 No. 3 p.180 ~ p.183
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Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen
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Pacharn Punchama
Siripipattanamongkol Nunthana
Veskitkul Jittima
Jirapongsananuruk Orathai
Visitsunthorn Nualanong
Vichyanond Pakit
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Abstract
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We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.
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KEYWORD
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Immunologic desensitization, Wheat allergy
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